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Controlled and Targeted Release of Natural Drugs

In medicine more effective methods using less toxic drugs and novel therapeutic strategies are necessary. Natural compounds can be promising sources for drug discovery. Numerous plant constituents are clinically used in the modern medicines, while many phytochemicals possess the potential to become novel therapeutics. Secondary metabolites of plants, such as steroids, terpenoids, flavonoids, alkaloids, are biologically active agents. Most beneficial properties of these substances are anti‑inflammatory, anti‑oxidative, anti‑diabetic, anti‑thrombotic, anti-arthritic, anti-amyloid, anti-ischemic or neuroprotective effects.

Some of the bio-originated compounds are specifically toxic on cancer cells compared to the normal cells, e.g., some essential oils have been proved to be able to modify apoptosis and cell cycle progression. Polyphenols and vitamin D also showed promising results in alternative chemotherapy. The antitumor effects of these compounds can be the result of DNA topoisomerase inhibition, anti-protease or antioxidant activity, and so on. The immune system stimulation, decrease of side effects of traditional drugs, overcoming resistance to chemo- and radiotherapy, synergistic drug interactions combined with other therapeutics can also be the beneficial effects of natural compounds.

Natural drugs can be more efficient if applied in controlled or targeted drug delivery systems. This special issue welcomes both review and original research articles that study chemical and physical methods for sustaining the release or presenting targeting strategies of bio-originated therapeutics.

Tivadar Feczkó

Guest Editor

Submission Deadline: 30 November 2019

Online Submission

Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Pharmaceutical Frontiers and then gathered together on the special issue webpage.

See Papers Published in This Special Issue


Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.

All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.

Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.

Guest Editor

  • Tivadar Feczkó

    Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences

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