University of Nebraska Medical Cente, USA
Department of Pathology & Microbiology, University of Nebraska Medical Cente, USA
Dr. Guangshun Wang is an Associate Professor at the University of Nebraska Medical Center (Omaha, Nebraska, USA). He is interested in developing novel compounds to treat human diseases, such as drug-resistant superbugs, viruses and cancer. His laboratory utilizes an integrated approach by combining chemistry, biophysics, bioinformatics, genetics, and structural biology. Two general methods are exploited to identify novel drug candidates. First, library screen is used. To search and screen starting templates, his laboratory has constructed the Antimicrobial Peptide Database (http://aps.unmc.edu/AP), which is widely utilized. As of July 2018, this database contained 2987 antibacterial, antiviral, antifungal, anti-parasitic and anticancer peptides, primarily from natural sources, covering the six life kingdoms (bacteria, archaea, fungi, protists, plants, and animals). Second, structure-based design is conducted. The lab uses multidimensional nuclear magnetic resonance (NMR) spectroscopy to determine the 3D structure of important peptides such as human cathelicidin LL-37, anticancer peptide aurein 1.2 and a helical Trp-rich peptide TetraF2W-RK. Recently, his laboratory has also combined the library approach with structure-based design to obtain compounds with drug-like properties. Dr. Wang has published 98 journal articles, invited reviews, and book chapters. In addition, he has edited a book entitled "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies" (CABI, 1st version 2010; 2nd version 2017). Dr. Wang also serves as an Associate Editor for Current Organic Chemistry and a guest editor for two special issues on antimicrobial peptides published in Pharmaceuticals.